Personalizing cancer drug treatment through engineering
patient-specific tumor models
In the Translational Tumor Engineering (TTE) lab, we focus on reconstructing and maintaining patient tumors in vitro with fidelity by using biomaterials engineering to recreate the tumor microenvironment.
Bottom-up: By incorporating appropriate biochemical and mechanical cues using biomaterials engineering, together with key tumor stromal cells, we RECONSTRUCT patient tumors as REVERSE ENGINEERED TUMORS (RETs).
Top-down: By engineering ex vivo conditions to PROLONG the viability of slices of tumors as is, we maintain patient tumors for drug testing and mechanistic studies.
We believe these models will aid in prediction of drug efficacy in patients and enable personalized treatment, patient by patient.