Department of Biomedical Engineering National University of Singapore
The TTE group leverages biomaterials to engineer in vitro and ex vivo tumors for personalized drug testing
Christabella Adine, Ph.D.
I completed my Ph.D. in Tissue Engineering and Regenerative Medicine from the National University of Singapore (NUS) in 2019. I have interest in both translational research and personalized medicine. During my Ph.D., I developed an organoid-based bio-functional 3D salivary gland system to treat patients with radiotherapy-induced dry mouth. I am currently a Research Fellow in the TTE Lab and we are working towards developing personalized tumor models for head and neck cancer patients.
I graduated from NUS with a Bachelor of Science (Honours) in Life Sciences (specialization in molecular and cell biology) in 2020. My research interests lie in developing human cell-based models that can more accurately predict patient response to drug therapies. I am currently a President's Graduate Fellowship scholar and Ph.D. student under Dr. Eliza Fong, working to develop tumour models of head and neck cancers for personalized medicine.
Elekuttige Anton Kanishka Fernando
I completed my Bachelor of Engineering with first-class honours in Mechanical Engineering with Management from the University of Liverpool. During my undergraduate studies, I developed human eye models to determine the increase in internal eye pressure caused during different tonometry techniques. I completed my Master of Science in Biomaterials from the University of Manchester where I was involved in developing novel biosensors using enzyme bioconjugates. I then worked for MAS Holdings for seven years as a technology entrepreneur to develop innovative solutions focused on addressing the needs of women’s reproductive cycle. I am currently a NUS Research Scholar focused on developing biomaterial engineering strategies to develop tumor models.
Wu Zhuoran Kenny
I completed my Bachelor of Engineering from South China University of Technology (SCUT) in 2016 and Master of Engineering from Nanyang Technological University (NTU) in 2018. I specialized in nanomaterials and macromolecular materials for biological applications where I developed an advanced encapsulation system that comprises a polymeric capsule capable of sustained release of Vitamin E and an amino acid-guided therapy that works well against mammary carcinoma. I am currently a doctoral student with a primary research focus on developing tumor microenvironment - mimetic hydrogels/microfluidics for in vitro tumor slice culture and high-throughput drug testing.
I graduated from SWJTU with a Bachelor of Engineering in Biomedical Engineering in 2020. My previous research experiences were related to development of multifunctional cardiovascular stents and using 3D bioprinting for cardiac tissue repair. I am currently a NUS Research Scholar focused on constructing in vitro models to recapitulate the heterogeneity of cancer-associated fibroblasts (CAFs).
I completed my masters in Biomedical Engineering at the National Research Bauman Moscow State University in 2015 and subsequently worked as a research engineer at a tissue engineering start-up focusing on 3D bioprinting. Currently I am pursuing my Ph.D. in the TTE lab where I focus on recapitulating cancer-stromal interactions with organoids using hydrogels.
I joined the TTE lab at the end of 2022 as an ISEP student, after graduating from Imperial College London with a BSc in Medical Biosciences. My project focuses on generating heterogeneous tumor-associated macrophages in head and neck squamous cell carcinoma.
I am a Year 3 undergraduate student from National University in Singapore (NUS) majoring in Biomedical Engineering (BME) with a second major in Life Sciences. I am currently completing my Undergraduate Research Opportunity Program (UROP) with a research focus on understanding how hydrogels can be leveraged for tumor slice culture.